EVALUASI PARAMETER HEMATOLOGI PADA PASIEN TUBERKULOSIS PARU DI KOTA BANDAR LAMPUNG
DOI:
https://doi.org/10.33088/jmk.v15i2.864Keywords:
Diagnosis, Profil Hematologi, TuberkulosisAbstract
Correct early diagnosis is crucial to control pulmonary tuberculosis infection (TB). This study aims to evaluate hematological parameters in tuberculosis patients to obtain parameters that can support the initial diagnosis of tuberculosis. A total of 36 patients diagnosed with TB based on rapid molecular tests and sputum smears compared the results of their hematological examination with 28 healthy volunteers according to age and sex. The routine blood tests examined were Hb, Ht, erythrocyte index, erythrocytes, leukocytes, and platelets count. TB patients had significantly lower Hb, Ht, MCV, and MCH mean levels compared to the healthy volunteer group (p<0.05). TB patients also had a significantly higher mean leukocyte and platelets count than the healthy volunteer (p<0.001). Conclusion: Hb, Ht, MCV, MCH, and leukocytosis decrease can be used as supporting diagnostic for the initial diagnosis of TB.
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References
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Renshaw, A.A., Gould, E.W. (2013). Thrombocytosis is associated with Mycobacterium tuberculosis infection and positive acid-fast stains in granulomas. Am J Clin Pathol. 139(5): 584–6. DOI: 10.1309/AJCPCM1CKASVBMBP
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Rohini, K., Bhat, M.S., Srikumar, P.S., Kumar, A.M. (2016). Assesment of hematological parameters in pulmonary tuberculosis patients. Indian J Clin Biochem. 31(3): 332–5. DOI: 10.1007/s12291-015-0535-8
Sari, K.S., Aryati. (2012). Nilai diagnostik antigen TB dengan rapid test device (TB AG) untuk tuberkulosis paru. Indonesia Journal of Clinical Pathology and Medical Laboratory. 18(3): 161–7. DOI: http://dx.doi.org/10.24293/ijcpml.v18i3.381
Shafee, M., Abbas, F., Ashraf, M., Mengal, M.A., Kakar, N., Ahmad, Z., et al. (2014). Hematological profile and risk factors associated with pulmonary tuberculosis patients in Quetta, Pakistan. Pak J Med Sci. 30(1): 36–40. DOI: 10.12669/pjms.301.4129.
Steingart, K.R., Ramsay, A., Pai, M. (2007). Optimizing sputum smear microscopy for the diagnosis of pulmonary tuberculosis. Expert Rev Anti Infect Ther. 5(3): 327–31. DOI: 10.1586/14787210.5.3.327
Tozkoparan, E., Deniz, O., Ucar, E., Bilgic, H., Ekiz, K. (2007). Changes in platelet count and indices in pulmonary tuberculosis. Clinical Chemistry and Laboratory Medicine. 45(8): 1009–13. DOI: 10.1515/CCLM.2007.194
Yaranal, P.J., Umashankar, T., Harish, S.G. (2013). Hematological pro?le in pulmonary tuberculosis. Int J Health Rehabil Sci. 2(1): 50–55.
Abdelkareem Y., Hashim, A.M., Abdelazeem, H. (2020). Hematological changes in pulmonary tuberculosis. Al Azhar Assiut Medical Journal. 13(4): 224–30.
Alamlih, L., Albakri, M., Ibrahim, W.H., Khan, A., Khan, F.Y. (2020). Hematological characteristics of patients with active pulmonary, extra pulmonary and disseminated tuberculosis: A study of over six hundred patients. Journal of Tuberculosis Research. 8(2): 33–41. DOI: 10.4236/jtr.2020.82004
Banerjee, M., Chaudhary, B.L., Shukla, S. (2015). Hematological profile among pulmonary tuberculosis patients in tertiary care hospital. International Journal of Bioassays. 4(5): 3900–02.
Balepur, S.S., Schlossber, D. (2016). Hematologic complications of tuberculosis. Microbiol Spectr. 4(6): 1-10.DOI: 10.1128/microbiolspec.TNMI7-0004-2016
Bozoky, G., Ruby, E., Goher, I., Toth, J., Mohos, A. (1997). Hematological abnormalities in pulmonary tuberculosis. Orv Hetil. 138(17): 1053–6.
Cattamanchi, A., Davis, J.L., Pai, M., Huang, L., Hopewell, P.C., Steingart, K.R. (2010). Does bleach processing increase the accuracy of sputum smear microscopy for diagnosing pulmonary tuberculosis. Journal of Clinical Microbiology. 48(7): 2433–9. DOI:https://doi.org/10.1128/JCM.00208-10
Ebrahim, O., Folb, P.I., Robson, S.C., Jacobs, P. (1995). Blunted erythropoietin response to anaemia in tuberculosis. Eur J Haematol. 55(4): 251–4. DOI: 10.1111/j.1600-0609.1995.tb00267.x.
Kahase, D., Solomon, A., Alemayehu, M. (2020). Evaluation of peripheral blood parameters of pulmonary tuberculosis patients at St. Paul's Hospital Millenium Medical College, Adis Ababa, Ethiopia: comparative study. Journal of Blood Medicine. 11: 115-121. DOI: 10.2147/JBM.S237317
Kartaloglu, Z., Cerrahoglu, K., Okutan O., Ozturk, A., Aydilek, R. (2001). Parameters of blood coagulation in patients with pulmonary tuberculosis. The Internet Journal of Internal Medicine. 2(2): 11-17.
Kurup, R., Flemming, K., Daniram, S., James, S.M., Martin, R.R. (2016). Hematological and biochemsitry profile and risk factors associated with pulmonary tuberculosis patients in Guyana. Tuberculosis Research and Treatment. 2016(1): 1–7. DOI: 10.1155/2016/6983747
Lee, M.Y., Kim, Y.J., Lee, H.J., Cho, S.Y., Park, T.S. (2016). Mean platelet volume in Mycobacterium tuberculosis infection. Biomed Research International. 2016(1): 1–4. DOI: https://doi.org/10.1155/2016/7508763
Rajesh, H., Sangeetha, B.S., Indhu, S., Manimaran, Nishanth, M. (2020). Evaluation of hematological profile in pulmonary tuberculosis. Indian Journal of Pathology and Oncology. 7(1): 39–42. DOI: https://doi.org/10.18231/j.ijpo.2020.008
Renshaw, A.A., Gould, E.W. (2013). Thrombocytosis is associated with Mycobacterium tuberculosis infection and positive acid-fast stains in granulomas. Am J Clin Pathol. 139(5): 584–6. DOI: 10.1309/AJCPCM1CKASVBMBP
Rodrigues, P.N., Gomes, S.S., Neves, J.V., Gomes, P.S., Correia, N.M., Nunes, A.C., et al. (2011). Mycobacteria-induced anaemia revisited: a molecular approach reveals the involvement of NRAMP1 and lipocalin-2, but not of hepcidin. Immunobiology. 216(10): 1127–34. DOI: 10.1016/j.imbio.2011.04.004.
Rohini, K., Bhat, M.S., Srikumar, P.S., Kumar, A.M. (2016). Assesment of hematological parameters in pulmonary tuberculosis patients. Indian J Clin Biochem. 31(3): 332–5. DOI: 10.1007/s12291-015-0535-8
Sari, K.S., Aryati. (2012). Nilai diagnostik antigen TB dengan rapid test device (TB AG) untuk tuberkulosis paru. Indonesia Journal of Clinical Pathology and Medical Laboratory. 18(3): 161–7. DOI: http://dx.doi.org/10.24293/ijcpml.v18i3.381
Shafee, M., Abbas, F., Ashraf, M., Mengal, M.A., Kakar, N., Ahmad, Z., et al. (2014). Hematological profile and risk factors associated with pulmonary tuberculosis patients in Quetta, Pakistan. Pak J Med Sci. 30(1): 36–40. DOI: 10.12669/pjms.301.4129.
Steingart, K.R., Ramsay, A., Pai, M. (2007). Optimizing sputum smear microscopy for the diagnosis of pulmonary tuberculosis. Expert Rev Anti Infect Ther. 5(3): 327–31. DOI: 10.1586/14787210.5.3.327
Tozkoparan, E., Deniz, O., Ucar, E., Bilgic, H., Ekiz, K. (2007). Changes in platelet count and indices in pulmonary tuberculosis. Clinical Chemistry and Laboratory Medicine. 45(8): 1009–13. DOI: 10.1515/CCLM.2007.194
Yaranal, P.J., Umashankar, T., Harish, S.G. (2013). Hematological pro?le in pulmonary tuberculosis. Int J Health Rehabil Sci. 2(1): 50–55.
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Published
2022-12-28
How to Cite
Yuniza, F., Nuraini, S., & Danan Jaya, B. P. (2022). EVALUASI PARAMETER HEMATOLOGI PADA PASIEN TUBERKULOSIS PARU DI KOTA BANDAR LAMPUNG. JURNAL MEDIA KESEHATAN, 15(2), 154–163. https://doi.org/10.33088/jmk.v15i2.864
