PENGGUNAAN BERBAGAI MACAM VAKSIN PADA TERAPI KONDILOMA AKUMINATA ANOGENITAL
DOI:
https://doi.org/10.33088/jmk.v14i2.709Keywords:
Anogenital condyloma acuminata, immunotherapy, vaccineAbstract
Anogenital condyloma aquiminata (AAC) is an anogenital Human papillomavirus (HPV) infection that usually manifests as papules or soft plaques on the external genitalia, perianal, perineal, or inguinal skin. In Indonesia, 13 hospitals (RS) with genital skin specialist education centers, there has been an increase in cases of condyloma acuminata in the last 5 years (2007-2011). In the Polyclinic of the Division of Sexually Transmitted Infections (STI) of the Dr. M DJamil Hospital, Padang, in 2019 there were 36 new cases and the total visits of condyloma acuminata patients who were controlled during 2019 were 288 visits. KAA therapy that is currently developing still shows a fairly high recurrence rate. Immunotherapy using vaccines has begun to be developed as an alternative therapy for AAC. The HPV vaccines, Mumps Measles Rubella (MMR), Bacillus Calmette-Guerin (BCG), and Mycobacterium indicus pranii (MIP) provide therapeutic benefit in AAC. The use of the HPV vaccine can be done intralesionally or intramuscularly. MMR and BCG vaccines are injected intralesionally. Meanwhile, the MIP vaccine was administered intradermally to both deltoids. The whole vaccine is given in several doses at different time intervals. Cellular immune stimulation is thought to be the basis for the usefulness of vaccines as therapy in AAC. There are no studies that reveal the side effects of giving vaccines as immunotherapy in AAC that are significant.
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References
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Singh, S., Chouhan, K. and Gupta, S. (2014) ‘Intralesional immunotherapy with killed Mycobacterium indicus pranii vaccine for the treatment of extensive cutaneous warts’, Indian Journal of Dermatology, Venereology and Leprology, 80(6), pp. 509–514. doi: 10.4103/0378-6323.144145.
Skeate, J. G. et al. (2016) ‘Current therapeutic vaccination and immunotherapy strategies for HPV-related diseases’, Human Vaccines and Immunotherapeutics, 12(6), pp. 1418–1429. doi: 10.1080/21645515.2015.1136039.
Song, D., Li, H. H. and Dai, J. (2015) ‘Effect of human papillomavirus infection on the immune system and its role in the course of cervical cancer’, Oncology Letters, 10(2), pp. 600–606. doi: 10.3892/ol.2015.3295.
La Torre, G. et al. (2017) ‘The effectiveness of measles-mumps-rubella (MMR) vaccination in the prevention of pediatric hospitalizations for targeted and untargeted infections: A retrospective cohort study’, Human Vaccines and Immunotherapeutics, 13(8), pp. 1879–1883. doi: 10.1080/21645515.2017.1330733.
W, I. and F., Z. (2017) ‘Kondiloma Akuminata’, in Infeksi menular seksual. 5th edn. Jakarta: Badan Penerbit Fakultas Kedokteran Universitas Indonesia, pp. 176–187.
Wilvestra, S. (2017) ‘Insiden kondiloma akuminata pada lelaki seks lelaki (LSL) di RS. Dr. M. Djamil Padang periode 2015-2016’, in Kongres Nasional Perdoski ke XV. Semarang.
World Health Organization (2014) Safety of Immunization during Pregnancy A review of the evidence, Who. Geneva: World Health Organization.
Anum, Q. et al. (2016) ‘Manifestasi klinis KA pada pasien poliklinik kulit dan kelamin RS. Dr. M. Djamil, Padang’, Media Dermatologica-venereologica Indonesiana, 43(3), pp. 89–93.
Bali, P. and Rafi, A. (2011) ‘Immunological mechanisms of vaccination’, Nature Immunology, 12(6), pp. 509–517.
Center for Disease Control and Prevention (2013) ‘Incidence , Prevalence , and Cost of Sexually Transmitted Infections in the United States’, CDC Fact Sheet, 40(February), pp. 1–4.
Centers for Disease Control and Prevention (CDC) (2020) General Best Practice Guidelines for Immunization: Best Practices Guidance of the Advisory Committee on Immunization Practices (ACIP).
Choi, H. (2019) ‘Can quadrivalent human papillomavirus prophylactic vaccine be an effective alternative for the therapeutic management of geniatl wart?? an exploratory study’, IBJU?: HPV Prophylactic vaccine as an therapeutic option warts, 45(2), pp. 361–378.
Covián, C. et al. (2019) ‘BCG-Induced Cross-Protection and Development of Trained Immunity: Implication for Vaccine Design’, Frontiers in Immunology, 10(November), pp. 1–14. doi: 10.3389/fimmu.2019.02806.
Data Laporan Tahunan Poliklinik Kulit dan Kelamin RSUP Dr M Djamil Padang tahun Januari 2020-Februari 2021. (2021).
Dhakar, A. K. et al. (2016) ‘Intralesional Mycobacterium w vaccine versus cryotherapy in treatment of refractory extragenital warts: A randomized, open-label, comparative study’, Journal of Cutaneous Medicine and Surgery, 20(2), pp. 123–129. doi: 10.1177/1203475415616962.
Ebrahim, H. M. et al. (2021) ‘Bacillus Calmette-Guerin polysaccharide nucleic acid vs Bacillus Calmette-Guerin vaccine in the treatment of warts: A comparative, double-blind, controlled study’, Dermatologic Therapy, 34(1), pp. 1–9. doi: 10.1111/dth.14549.
Gondo, H. K. (2009) ‘Vakisn Human Papilloma Virus (HPV) untuk Pencegahan Kanker Serviks Uteri’, Jurnal Ilmiah Kedokteran, I(1), p. 88.
Gupta, A. et al. (2012) ‘Efficacy of Mycobacterium indicus pranii immunotherapy as an adjunct to chemotherapy for tuberculosis and underlying immune responses in the lung’, PLoS ONE, 7(7), pp. 1–12. doi: 10.1371/journal.pone.0039215.
Gupta, A. et al. (2019) ‘Mycobacterium indicus pranii Induced Memory T-Cells in Lung Airways Are Sentinels for Improved Protection Against M.tb Infection’, Frontiers in Immunology, 10(October), pp. 1–18. doi: 10.3389/fimmu.2019.02359.
Gupta, S. K. (2010) ‘The management of vulvovaginal warts using intralesional Bacillus Calmette–Guérin immunotherapy’, Indian Journal of Sexually Transmitted Diseases and AIDS, 41(2), pp. 204–207. doi: 10.4103/ijstd.IJSTD.
Hur, Y. G. et al. (2014) ‘Factors affecting immunogenicity of BCG in infants, a study in Malawi, The Gambia and the UK’, BMC Infectious Diseases, 14(1), pp. 1–10. doi: 10.1186/1471-2334-14-184.
Indriatmi, W. (2012) ‘Epidemiologi Infeksi Menular Seksual’, in Simposium Sexually Transmitted Infections A rising concern. Semarang.
Khullar, G. et al. (2017) ‘Recalcitrant giant condyloma acuminatum treated successfully with a novel combination of Mycobacterium indicus pranii immunotherapy and acitretin’, International Journal of STD and AIDS, 28(11), pp. 1155–1157. doi: 10.1177/0956462417694805.
Kim, Hyoung Jin and Kim, Hong Jin (2017) ‘Current status and future prospects for human papillomavirus vaccines’, Archives of Pharmacal Research, 40(9), pp. 1050–1063. doi: 10.1007/s12272-017-0952-8.
Nacianceno, P. A., Camaclang, M. L. A. and Roa, F. D. C. (2019) ‘Intralesional measles, mumps, and rubella vaccine for cutaneous warts: A Systematic Review and Meta-analysis’, Acta Medica Philippina, 53(2), pp. 162–170. doi: 10.47895/amp.v53i2.211.
Navarro-Illana, E. et al. (2017) ‘Effectiveness of HPV vaccines against genital warts in women from Valencia, Spain’, Vaccine, 35(25), pp. 3342–3346. doi: 10.1016/j.vaccine.2017.04.080.
Nofal, A. et al. (2020) ‘Intralesional versus intramuscular bivalent human papillomavirus vaccine in the treatment of recalcitrant common warts’, Journal of the American Academy of Dermatology, 82(1), pp. 94–100. doi: 10.1016/j.jaad.2019.07.070.
Patel, H. et al. (2013) ‘Systemic review of the incidence and prevalence of genital warts. MBC Infection Disease’, MBC Infection Disease, 13(39), pp. 1–14.
Pennycook, K. B. and McCready, T. A. (2021) Condyloma Acuminata, StatPearls.
Pollard, A. J. and Bijker, E. M. (2021) ‘A guide to vaccinology: from basic principles to new developments’, Nature Reviews Immunology, 21(2), pp. 83–100. doi: 10.1038/s41577-020-00479-7.
Rajegowda, H. M. et al. (2020) ‘Intralesional measles, mumps, and rubella vaccine versus cryotherapy in treatment of warts: A prospective study’, Journal of Dermatology and Dermatologic Surgery, 24(2), pp. 9–11. doi: 10.4103/jdds.jdds.
Rodriguez-Coira, J. and Sokolowska, M. (2021) ‘SARS-CoV-2 candidate vaccines - composition, mechanisms of action and stages of clinical development’, Allergy: European Journal of Allergy and Clinical Immunology, 00(December 2020), pp. 1–3. doi: 10.1111/all.14714.
Sharma, S. and Agarwal, S. (2020) ‘Intralesional Immunotherapy with Measles Mumps Rubella Vaccine for the Treatment of Anogenital Warts: An Open-label Study.’, The Journal of clinical and aesthetic dermatology, 13(8), pp. 40–44.
Singh, S., Chouhan, K. and Gupta, S. (2014) ‘Intralesional immunotherapy with killed Mycobacterium indicus pranii vaccine for the treatment of extensive cutaneous warts’, Indian Journal of Dermatology, Venereology and Leprology, 80(6), pp. 509–514. doi: 10.4103/0378-6323.144145.
Skeate, J. G. et al. (2016) ‘Current therapeutic vaccination and immunotherapy strategies for HPV-related diseases’, Human Vaccines and Immunotherapeutics, 12(6), pp. 1418–1429. doi: 10.1080/21645515.2015.1136039.
Song, D., Li, H. H. and Dai, J. (2015) ‘Effect of human papillomavirus infection on the immune system and its role in the course of cervical cancer’, Oncology Letters, 10(2), pp. 600–606. doi: 10.3892/ol.2015.3295.
La Torre, G. et al. (2017) ‘The effectiveness of measles-mumps-rubella (MMR) vaccination in the prevention of pediatric hospitalizations for targeted and untargeted infections: A retrospective cohort study’, Human Vaccines and Immunotherapeutics, 13(8), pp. 1879–1883. doi: 10.1080/21645515.2017.1330733.
W, I. and F., Z. (2017) ‘Kondiloma Akuminata’, in Infeksi menular seksual. 5th edn. Jakarta: Badan Penerbit Fakultas Kedokteran Universitas Indonesia, pp. 176–187.
Wilvestra, S. (2017) ‘Insiden kondiloma akuminata pada lelaki seks lelaki (LSL) di RS. Dr. M. Djamil Padang periode 2015-2016’, in Kongres Nasional Perdoski ke XV. Semarang.
World Health Organization (2014) Safety of Immunization during Pregnancy A review of the evidence, Who. Geneva: World Health Organization.
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Published
2021-12-31
How to Cite
Wirman, J., & Anum, Q. (2021). PENGGUNAAN BERBAGAI MACAM VAKSIN PADA TERAPI KONDILOMA AKUMINATA ANOGENITAL. JURNAL MEDIA KESEHATAN, 14(2), 103–117. https://doi.org/10.33088/jmk.v14i2.709
